Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
Identifieur interne : 004C16 ( Main/Exploration ); précédent : 004C15; suivant : 004C17Prox1 dosage controls the number of lymphatic endothelial cell progenitors and the formation of the lymphovenous valves
Auteurs : R. Sathish Srinivasan ; Guillermo OliverSource :
- Genes & Development [ 0890-9369 ] ; 2011.
Abstract
In characterizing the embryonic lymphovenous valves that control the communication between the blood and lymphatic vasculature, it is found that these valves are formed by intercalation of Prox1+ lymphatic endothelial cells (LECs) with Prox1+ ECs present in adjacent veins. Prox1 heterozygous embryos lack this valve formation due to a reduction in the number of Prox1+ ECs and LEC progenitors caused by reduced Coup-TFII/Prox1 complex formation.
Url:
DOI: 10.1101/gad.16974811
PubMed: 22012621
PubMed Central: 3205588
Affiliations:
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Le document en format XML
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